Incretin agonists
Retatrutide
Also listed as LY3437943
GLP-1, GIP and glucagon receptor tri-agonist peptide
- GLP-1R
- GIPR
- GCGR
- Formula
- C221H342N46O68
- Molar mass
- 4731.35 g/mol
- CAS number
- Not quoted
Identity
What the molecule is, from the PubChem records that exist for it. These are the figures a certificate of analysis should agree with.
- Class
- GLP-1, GIP and glucagon receptor tri-agonist peptide
- Sequence
- Not quoted See note
- Molecular formula
- C221H342N46O68
- Molar mass
- 4731.35 g/mol
- CAS number
- Not quoted See note
- PubChem
- Not quoted See note
PubChem has no parent record for retatrutide yet. The formula and mass are the ones shared by its unparented compound records (for example CID 171390338). Without a parent record we don’t quote a sequence or CAS number.
Checked against PubChem on 27 September 2026. Molar mass is calculated from the formula with standard atomic weights and agrees with PubChem’s published molecular weight.
Research context
Retatrutide is a single lipidated peptide designed to activate three related class B receptors: the GLP-1, GIP and glucagon receptors. Laboratory work measures its potency at each receptor separately, usually as cAMP accumulation in cell lines that each express one human receptor. Because its fatty diacid chain binds serum albumin, in vitro assays often report results with and without albumin present.
Research use only. Everything on Vialwise concerns research-grade material sold for laboratory and analytical use only. It is not a registered medicine, is not supplied for human or veterinary use, and nothing here is medical advice.
Storage and handling
Store sealed lyophilised powder at −20 °C, dry and away from light.
Let the vial reach room temperature before opening, so moisture doesn’t condense on the powder.
The fatty diacid side chain slows dissolution and makes the peptide cling to plastic. Give it time to dissolve fully and use low-binding tubes.
Split the solution into single-use aliquots and keep them frozen, so no portion goes through repeated freeze–thaw.
General laboratory practice for this class of material; your institution’s own procedures come first. To work out concentration and aliquot volumes from a vial’s mass, use the reconstitution calculator. For the reasoning behind each step, read storing lyophilised peptides.
Published lab reports
Lab reports for Retatrutide at Au Peptide Labs Our store
The one supplier whose full report list we have.
Open each lab-linked report on the lab’s own website to confirm it.
- Lab link
GLP-1 LR3
Task #124033Added 31 July 2026
Verify at janoshik.com99.554%purity
Other suppliers publish their reports on their own sites. Where each supplier publishes its COAs
Vialwise is published by APL Research Pty Ltd, which also runs Au Peptide Labs. Every supplier, ours included, is scored on the same published checklist. How we handle this
Any supplier
Check any supplier’s Retatrutide COA
These checks take a few minutes and work the same on a report from any supplier, ours included. The walkthrough shows each one on a real Janoshik report.
How to verify a Janoshik COAOpen it at the lab
The report should load on the testing lab’s own website from the verify link or task number, not only as a PDF or screenshot from the supplier.
Match the name
The sample should be named Retatrutide or LY3437943, or a clear equivalent. A different compound name means a different report.
Match the mass
If the report includes a mass-spectrometry result: a deconvoluted average-mass result should sit close to 4731.35 g/mol; high-resolution reports give the slightly lower monoisotopic mass, and raw spectra show m/z for charged ions (mass ÷ charge). How HPLC and mass spec work.
Match the vial
The sample amount on the report should match the vial size you’re buying. A report on a different size or an older batch tells you less about the vial in front of you.
Related
Related compounds
Incretin agonists
Semaglutide
GLP-1 receptor agonist peptide (lipidated GLP-1 analogue)
C187H291N45O594113.58 g/mol